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Tips to get softer sheets


New sheets often have a stiffness that can affect our comfort when sleeping

One of the best times of the day for many people comes when the sun goes down and we can end the day. After the accumulated exhaustion throughout the day, opening the bed and getting into it is one of life’s priceless pleasures. Gently resting our body on the soft bed and feeling how the sheets brush against us is a most pleasant sensation. But, to get the best possible rest and to be able to enjoy this little pleasure for a long time, it is important to bother during the day to make the bed and take care of the washing of the sheets and blankets.

And it is that the soft touch, the subtle aroma, and the absence of wrinkles are important elements to get the best feeling and rest in the best possible way. Ideally, so that the sheets are soft and free of mites, various fibers, or hair, it is advisable to change them at least once every fifteen days. Although it does not hurt to wash them once a week.

Sometimes when the sheets are new, we may find that they feel stiffer than normal. This occurs as a result of chemical residues leftover from the manufacturing process. But with a few simple tricks, we can speed up the process of softening the sheets.

The regular cycle of the washing machine

This program is indicated to make the sheets come out softer from the washing machine. Regular warm water cycling will help to get rid of that uncomfortable stiffness.

Hang the sheets on a clothesline

When we finish washing the sheets we can hang them on a clothesline to dry in the sun, which will help soften them. As an alternative, we can also put them in the dryer with a low-temperature program, to prevent them from shrinking.

Add baking soda

A cup of baking soda to replace your regular detergent can make your sheets softer out of the washing machine. But, it is important that you avoid using detergent so that its chemicals increase the rigidity.

Pour a cup of vinegar

When the rinse cycle is about to begin we can pour a cup of white vinegar to help soften our sheets.

Use baking soda and vinegar

If the last two tricks help to eliminate the stiffness of the sheets, combining the two is even more effective. Combine the power of baking soda and vinegar in the washing machine to be able to sleep with soft sheets and rest in total comfort.

Wash and wash again

If in the first uses we notice the very rigid sheets, we should not worry too much. We must be aware that as we use and wash them they will soften. We can also opt for a second wash before use if we want to speed up the process.

Buy quality sheets

If you are thinking of changing sheets and you have not bought them yet, you have to remember that the higher quality ones will also be more comfortable and soft. The higher the density of threads that make up the sheet, the better.


Eating and dining late and watching screens before bed makes you fat


A study shows that these types of habits have a direct impact on body fat indices

Eating and dining late and the use of screens before going to sleep has a direct impact on body fat levels and sets the rate of fat loss in a slimming process, in addition to increasing the risks of cardiovascular disease.

This is the main conclusion drawn from the different studies carried out in recent years by the research team of the University of Murcia (UMU) led by the professor of Physiology Marta Garaulet.

The results of these studies were made public throughout 2020 in six articles published by the main scientific journals dedicated to nutrition in Europe and the United States.

These are trials that unravel the reasons for the effect of hours of food intake; a path started in 2013 with the publication of the results of a study that opened the way to research in Chrono nutrition worldwide.

That first study, published in the International Journal of Obesity, and which has become one of the most cited in its field in the world, showed that eating after three in the afternoon slowed down the weight loss process.

Subsequent research in this line followed by Garaulet has just shown, in an article published in the American Journal of Clinical Nutrition, that not only late lunchtime has an influence, but that it is the entire daily mealtime pattern that is decisive as the cause of obesity and which has negative effects on health.

A study involving 3,660 individuals has shown that those with a late mid-point of intake are fatter, have higher triglycerides, and have greater insulin resistance; factors that determine an increased risk of cardiovascular disease.
And what is the mid-point of intake? Well, it is the result of the number of hours from the start of breakfast to dinner, divided by two, and added to breakfast time. For example, a person who has breakfast at 7:00 a.m. and dinner at 8:30 p.m. will have a mid-point of intake at 1:30 p.m. In another case, a person who eats breakfast at 10 a.m. and dines at 11 p.m. will have their midpoint of intake at 4.30 p.m.

This latest study by Garaulet has shown that each hour of a delay from that mid-point of intake implies a kilo less of weight loss in a process of 19 weeks of treatment.

The study of the behavior of the volunteers in this trial has also established that late eaters tend to eat more when stressed, that they do so mainly at night, compulsively, while watching television, and that they are less motivated to take care of themselves.

“These results should help to design specific therapies for late eaters, mainly help them control stress and establish routines that improve their habits,” explained Garaulet.

The metabolic reason why the time of ingestion influences so much has been found in an enzyme that helps the body to burn fat, and whose maximum activity is at night (J Clin Endocrinol Metab). When we have a late dinner, the activity of this enzyme decreases by one third.

It is Hormone Sensitive Lipase (LSH), whose activity changes throughout the day and the more it performs at midnight. A late dinner confuses this enzyme, which understands that it does not have to mobilize fat.

This study by Marta Garaulet’s team together with Dr. Juan Antonio Luján, from the Virgen de la Arrixaca Hospital in Murcia, has had the collaboration of researchers from Harvard, the Karolinska Institute in Stockholm, and the University of Granada.

Research indicates that the appropriate time for dinner is 2.5 hours before going to sleep, since dinner later than that time supposes, in addition to a greater propensity to obesity, an increase in blood glucose values.

In this sense, this has been shown to occur in people with a specific polymorphism in the melatonin receptor, which occurs in a significant part of the population (50 percent) (Trends Endocrinol Metab).

In children
The timing of the intakes not only influences adults but is also a problem that occurs in children. In this sense, a study carried out on schoolchildren between eight and twelve years old, and published in Nutrition, allows us to conclude that those who eat dinner after 8:45 p.m. are twice as obese as those who eat dinner before because they spend less energy metabolizing dinner foods.

In addition, research has shown that inflammation is 1.8 times greater in children who eat late than those who eat early, which influences higher levels of C-reactive protein (CRP), a risk marker for suffering. cardiovascular disease in the future.

In minors, the time of sleep is also of vital importance and, especially, the habits they have before going to sleep. Another study, also with schoolchildren of the same age group, yields results that indicate that those children who have an evening chronotype, that is, who are active in the last hours of the day, tend to be exposed to more light from screens before school. going to bed than the rest, up to more than 50 lux, is equivalent to having fifty candles lit at the same time near the face.

These habits can delay the activation of the nighttime hormone melatonin for up to three hours, delaying the sleep center and children awakening in full restorative sleep. The result is less effective schoolchildren, with poorer attention span, and with poorer academic grades in almost all areas.

Negative results are also observed in young adults through a study carried out in a population of individuals between 19 and 23 years of age from the Region of Murcia and Mexico (Clinical Nutrition). This study showed that those with an evening chronotype have higher triglycerides and risk of cardiovascular disease.

Grandma’s tricks to make your house cleaner


Vinegar and bicarbonate are always two great allies to keep your home sparkling

Who has not ever said that ‘this weekend I thoroughly clean the house’? But the moment does not come and the desire does not usually appear € basically because the task is usually so immense that it is not even known where to start. Before chaos takes over, clothes pile up in the bedroom and it is impossible to find anything in the closet, it is good to know that there are little tricks to keep your home cleaner and more orderly. Yes, those typical simple, cheap and effective grandmother resources.

The bicarbonate is one of the great allies of our grandmothers. Among many other things, it can be used to remove unpleasant odors from both the washing machine and the dishwasher . Simply pour a mixture of water and baking soda into the detergent compartment and run a wash program. White vinegar is also very effective for having a high disinfecting power, in addition to eliminating mold and bacteria that tend to accumulate in the rubber between the door of the washing machine and the interior of the drum.

Also, if the sofa or rugs give off a funny smell, you can also use baking soda. Nothing like spraying it, letting it act for about 15 minutes and then using the vacuum cleaner to remove it.

Speaking of strange smells, to get your home to maintain a good aroma it is only necessary to ventilate daily for about a quarter of an hour. Other tricks in this regard are cleaning the floor with hot water and lemon. But if you prefer to opt for air fresheners, it is advisable to place them next to the windows. In this way, the current will circulate the essence better throughout the house.

And the closet? It can also pick up unwanted odors, so some maintenance is important. First of all, garments should not be stored unwashed or at least ventilated. You can also hang lavender sachets or scented soap bars. Many times, grandmothers opt for apples, whose skin once dry is put into bags or quinces. Another option is to include cinnamon sticks.

The towels can rejuvenate two steps. The first is to add a cup of white vinegar to the load of the washing machine and run a program with hot water. Then put another wash adding half a cup of baking soda. Finally, it is enough to dry the towels in a ventilated place and that way they will smell good and will be much fluffier.

And from the bedroom to the bathroom. Always have a cloth and limescale on hand. It is not about cleaning it every day (something practically impossible), but it is about taking a short walk to the sink or mirror after using them. It takes just a few seconds, which makes it easier for this room to look cleaner on a daily basis.

If your bathroom has dampness, there is also a little trick. Simply put a container with chalk, rice, or charcoal and place it on a shelf. They are materials that absorb moisture and bad odors well.

If you do not know what to do with the wooden cutlery because they have darkened with use, simply submerge them in warm water mixed with hydrogen peroxide to achieve that natural wood tone that they had at the beginning.

Something similar can happen with the wooden cutting board. It should not be put in the dishwasher because it splinters. If it looks bad, it is best to apply mineral oil or beeswax, let it work for 24 hours, and remove the excess liquid.

Finally, another thing that usually brings us to head is how to end the coffee stains that spill on the tablecloth. Any grandmother would fix it by putting paper on top to absorb it and then adding sparkling water. A process that must be repeated several times, so that in each pass the stain disappears.


Education and awareness in the use of antimicrobials


Multi-resistant bacteria are a real threat to global public health. Increased use of antibiotic treatments reduces the effectiveness of future treatments

Antimicrobial drugs, especially antibiotics that target bacteria, are among the most precious medical resources today. Antibiotics are crucial to modern medicine, as they cure and even help prevent many types of infections. Without them, many routine procedures that carry a high risk of contracting infections, such as complex surgeries or the administration of immunosuppressive treatments to people with cancer, could not be performed.

However, these antibiotics must be administered rationally, and only when prescribed by the doctor, since the more they are used, the more pressure the bacteria have to develop resistance. As a consequence of their intensive use, microorganisms mutate and find ways to resist the effects of antibiotics. For this reason, antimicrobials are alarmingly losing their effectiveness: resistant pathogens survive, grow, and spread their resistance, causing more and more deaths and more pressure for care.

A global threat

The development and spread of multi-resistant bacteria is a real threat to global public health today, as recognized by the World Health Organization (WHO). These resistant bacteria produce up to 700,000 annual deaths in the world and, recently, it has been estimated that they could cause the death of 10 million people in the year 2050, surpassing cancer as the first cause of death.

In Spain, according to the Spanish Society for Infectious Diseases and Clinical Microbiology (SEIMC), the results are overwhelming, and each year, more than 35,000 people die with infections caused by multi-resistant bacteria. These data are worrying since they cause an increase in medical costs, a prolongation of hospital stays, and an increase in mortality.

Consequently, as stressed by the pharmaceutical company Pfizer, “extreme caution must be exercised in the use of this type of medicine.” In addition, as warned by the United Nations (UN) and the National Plan against Antibiotic Resistance of the Ministry of Health, the increase in the use of antibiotic treatments in the context of the pandemic caused by the coronavirus, could facilitate the development of resistant bacteria and reduce the effectiveness of future treatments.

Although covid-19 is a viral infection, there are patients with the possibility of secondary bacterial infection in whom antibiotic prescription should be considered. For this reason, this year it is more important than ever to try to avoid bacterial infections through vaccination and hand hygiene, common gestures in preventing the spread of flu, and covid-19.

Antimicrobial awareness

Aware of the current magnitude of the problem and committed to joining the effort led annually by WHO, the biopharmaceutical company Pfizer supports the 2020 World Antimicrobial Awareness Week to increase awareness of antimicrobial resistance. For this reason, this year it has launched the ‘Act Now-Stop Resistance’ campaign, based on a commitment document supported by all medical societies and patients involved and which seeks to be a call to action for the entire society.

This initiative, which has the support and collaboration of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Preventive Medicine, Public Health and Hygiene (SEMPSPH), the Spanish Society of Hospital Pharmacy (SEFH), the Spanish Society of Intensive, Critical Medicine and Coronary Units (SEMICYUC) and the Platform of Patient Organizations (POP) seek to promote awareness of antibiotic resistance, through their rational use and of the urgent need to promote awareness education and prevention education, through measures such as vaccination and key gestures such as hand hygiene.

How to easily clean your kitchen tiles


Fundamental tricks to make one of the parts of the house that accumulate the most dirt impeccable

The kitchen is one of the parts of the house that we use the most and that accumulate the most dirt. Therefore, it is important to stop cleaning it and take special care that it is as well cared for as possible.

One of the points where dirt is most focused on is the tiles. Especially in the areas closer to the fires or the glass-ceramic, more food debris can fly out and require a greater effort when cleaning.

We give you several tips so that your work on kitchen tiles is as complete as possible … and without entailing an excessive effort.

Put the order in your kitchen

The first thing you should do is move away from everything you have on the hob in the vicinity of these fires or the glass-ceramic. This will prevent them from getting wet. You can also remove what hangs on the walls that you want to clean, and even sweep the broom on the floor so that the dust does not cause more problems if it mixes with the water that falls from your cleaning.

Use soap and water

Take a basin, fill it with water, add some liquid soap, and use it to do the basic cleaning. With your scouring pad, you can use the soft part to remove light dirt and the rough part to scrub the most stubborn dirt. Then, remove the soap residue with a damp cloth and finish with kitchen paper or a last clean and dry cloth.

Ammonia or vinegar

The ammonia will help you disinfect some tiles or in cases where a lot of greases have accumulated. Prepare hot water mixed with this element, use rubber gloves for cleaning and ventilate the kitchen when cleaning. Rub the joints well, finish rinsing with water, and finish drying with a cloth. In the case of vinegar, the procedure is similar (a part of white vinegar for three of hot water in the mixture) and go over the end with a soaked cloth.

To clean the joints

If the gaps between tile and tile have become blackened or dirty, keep in mind that you can restore them to their original condition with specific products. Another option is to use baking soda. It will be worth two tablespoons mixed with water until you get a paste, which you can apply with a toothbrush. After a few minutes, you should remove it with a sponge.

Get the shine back

Using a glass cleaning product you can make the tiles look shinier. If you do this once a week, the effort required to maintain the shine will be much less and these will stay in better condition for much longer.

Father’s Day: original ideas for gifts during confinement


Discover what original gifts you can make yourself despite being confined at home

This year the Father’s Day holiday is undoubtedly exceptional. With all Spain in full quarantine, discover what homemade gifts you can make yourself at home. Get down to work and sign up for the following ideas to surprise your father. Homemade and very original gifts with which you will leave your parent speechless.

Homemade tablet sleeve

Get yourself a few sheets of foam rubber and shape your ideas. There are several ways to prepare homemade tablet covers. Choose the one that best suits your father’s needs or tastes and surprise him with this original and practical gift for Father’s Day.

Custom apron

If your father is passionate about cooking, you can take the opportunity to give him a personalized apron. You can buy an apron in a solid color and decorate it with a beautiful phrase, with your hands impregnated in paint or with the decorative motif that you like the most.

Lego pieces cufflinks

If you and your father have shared unforgettable moments playing with your Lego pieces, you can take advantage of Father’s Day to prepare an original gift. Collect a series of these fun pieces and place them on the base of some cufflinks. Your father will show them pride with his shirts.

Personalized card

We can also surprise you with a beautiful message inside an original card made by ourselves. We only need a couple of different colored cards, a ruler, scissors, colored paints, glue, and a little imagination to make the most original card for Father’s Day.


Eliminating meat from the diet increases the risk of fractures


The greatest differences were for hip fractures, where the risk in vegans was higher

Compared to meat-eaters, vegans with lower calcium and protein intake on average have a 43% higher risk of fractures anywhere in the body (total fractures), as well as a higher risk of site-specific fractures of hips, legs, and vertebrae, according to a study published in the open-access journal ‘BMC Medicine’.

The vegetarians and people who ate fish but no meat had a higher risk of hip fractures compared with people who ate meat. However, the risk of fractures was partially reduced once body mass index (BMI), dietary calcium, and dietary protein intake were taken into account.

Dr. Tammy Tong, a nutritional epidemiologist at the Nuffield Department of Population Health, University of Oxford, UK, and lead author highlights that “this is the first comprehensive study on the risks of total and specific fractures in people from different diet groups. “

Major differences for hip fractures

“We found that vegans had a higher risk of total fractures, resulting in about 20 more cases per 1,000 people over a 10-year period, compared to people who ate meat,” he continues. “The biggest differences were for hip fractures, where the risk in vegans was 2.3 times higher than in people who ate meat, equivalent to 15 more cases per 1,000 people in a period of 10 years. “

A team of researchers from the Universities of Oxford and Bristol analyzed data from nearly 55,000 people in the EPIC-Oxford study, a prospective cohort of men and women living in the United Kingdom, who were recruited between 1993 and 2001, many of whom do not eat meat.

Of the 54,898 participants included in the present study, 29,380 ate meat, 8,037 ate fish but not meat, 15,499 were vegetarians, and 1,982 were vegans when recruited. Their eating habits were initially assessed at the time of recruitment, then again in 2010.

The participants were followed continuously for 18 years on average until 2016 to detect the occurrence of fractures. During the time of the study, a total of 3,941 fractures occurred, including 566 of the arm, 889 of the wrist, 945 of the hip, 366 of the leg, 520 of the ankle, and 467 fractures at other major sites, defined as the clavicle, ribs and ribs vertebrae.
In addition to a higher risk of hip fractures in vegans, vegetarians, and pescetarians than meat-eaters, vegans also had an increased risk of leg fractures and other main site fractures.

The authors found no significant differences in risks between the diet groups for arm, wrist, or ankle fractures once BMI was taken into account. The authors found that the differences in total and site-specific fracture risk were partially reduced once BMI, dietary calcium, and dietary protein intake were taken into account.

Dr. Tong recalls that “previous studies have shown that a low BMI is associated with an increased risk of hip fractures, and low calcium and protein intake have been linked to poorer bone health. This study showed that vegans, who on average had a lower BMI as well as lower calcium and protein intake than meat-eaters, had a higher risk of fractures at various sites. “

” Well-balanced and predominantly plant-based diets can result in better nutrient levels and have been linked to lower risks of diseases, such as heart disease and diabetes,” he continues. “People should consider the benefits and risks of their diet and make sure you have adequate levels of calcium and protein and also maintain a healthy BMI, that is, neither underweight nor overweight. “

Researchers associate anxiety with the rapid onset of Alzheimer’s


The number of deaths from this disease has more than doubled since 2000

Anxiety is associated with a higher rate of progression from mild cognitive impairment to Alzheimer’s disease, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA).

Alzheimer’s represents a major crisis in the health public worldwide. The number of deaths from this disease has more than doubled since 2000, and it is currently the fifth leading cause of death among people 65 and older in the United States.

Many people with Alzheimer’s first experience mild cognitive decline, a decline in cognitive abilities such as memory and thinking skills that is faster than is normally associated with aging. Anxiety has been observed frequently in patients with mild cognitive impairment, although its role in the progression of the disease is not well understood.

“We know that the loss of volume in certain areas of the brain is a factor that predicts the progression of Alzheimer’s disease. In this study, we wanted to see if anxiety had an effect on the structure of the brain, or if the effect of anxiety it was independent of the structure of the brain to favor the progression of the disease “, explains the study’s lead author, Maria Vittoria Spampinato, professor of radiology at the Medical University of South Carolina in Charleston (United States).

The study group included 339 patients, with a mean age of 72 years, from the Alzheimer’s Disease Neuroimaging Initiative 2 cohort. Each person had a baseline diagnosis of mild cognitive impairment; 72 progressed to Alzheimer’s disease while 267 remained stable.

The researchers performed MRIs of the brain to determine the baseline volumes of the hippocampus and entorhinal cortex, two important areas for memory formation. They also tested for the presence of the APOE4 allele, the most prevalent genetic risk factor in Alzheimer’s disease. Anxiety was measured with established clinical studies.

As expected, patients progressing to Alzheimer’s had significantly smaller volumes in the hippocampus and entorhinal cortex and a higher frequency of the APOE4 allele. Most notably, however, the researchers found that anxiety was independently associated with cognitive decline.
“Patients with mild cognitive impairment with symptoms of anxiety developed Alzheimer’s disease faster than individuals without anxiety, regardless of whether they had a genetic risk factor for Alzheimer’s disease or loss of brain volume,” details the first author of the study, Jenny L. Ulber.

The relationship between anxiety symptoms and a more rapid progression of Alzheimer’s disease presents an opportunity to improve the assessment and management of patients with early mild cognitive impairment, according to the researchers.

“We need to better understand the association between anxiety disorders and cognitive decline. We don’t yet know if anxiety is a symptom – in other words, their memory is worsening and they become anxious – or if anxiety contributes to cognitive decline. If we were able in the future to find that anxiety is actually causing the progression, then we should more aggressively review anxiety disorders in the elderly, “concludes Spampinato.

Painting paper, the latest decor trend


If this technique reminds you of your grandmother’s house, in this article we warn you that you are wrong

If you are tired of the look of your home and do not know how to give it a change without involving a large investment, wallpaper can become your best ally. We also have to tell you that if when you read these words you immediately remembered your grandmother’s house, you are very, very wrong.

The elegance of habitat

Wallpaper has become an increasingly recurring decorative element, adapting to the latest fashions and trends. It is for this very reason that the Habitat interior design studio has reinvented paper by filling the walls with art. The brand’s proposals range from elegant color palettes to original drawings with plants, ethnic or naive figures … the three proposals for autumn-winter 2019-20 provide you with a variety of inspiration to dress your home.

Created by designer Floriane Jacques, CHARLIE wallpaper combines the straight lines of an architectural structure with the vegetative curves of imaginary trees and plants, revealing the contours of an elegant and fantastic urban jungle. A print for those who love to escape and dream, available in blue and ocher tones or in black and white.

NOUR has been inspired by batik, with an ethnic spirit. Conceived as an overlay of naive squares wedged together, this wallpaper reveals a multitude of lines juxtaposed with dense colors. Like a handmade collage, its subtle imperfections add authenticity and character to the print.

The paper OSCAR painted, also Floriane Jacques retakes the star print catalog 2019-20 in a black and white version. The design is a nod to recurring African masks in the work of Picasso, Modigliani, Braque, and other 20th-century avant-garde artists in a joyous tribute to the artistic flourishing of that era.

Botanical art on the walls

MuralsWallpaper has also unveiled its four new wallpapers for the new collection. For the creation, they have used detailed vintage paintings by Pierre-Joseph Redouté, considered masterpieces of botanical art.

With the various models bearing the Redouté name, the Vintage Botanicals collection brings its small and intricate illustrations to life once again, reinventing them as panoramic scenes of floral motifs and jungle-like plant life. Redouté’s original illustrations have been taken from his more than 200-year-old book ‘Les Liliacées’, which are reinterpreted into a collection of sophisticated wallpapers for flower lovers.

Solar feelings and joy on the wall

If wallpaper allows one thing, it is to bring a touch of joy and fun to our walls, and that is specifically what MuralsWallpaper does in its collection of ‘Solar Feelings’ typographic models.

The home can be a haven of positive feelings when it is filled with cheerful and personal designer decorations, which is why this collection has been designed by Lauren Kavanagh to spread a relaxing atmosphere in the environment, inspire and promote joy, letting the decoration show a little more love with powerful messages.

Why Does Something Disgusting Make Your Stomach Churn


Disgust is a natural response to unpleasant sights, like rotten food

Researchers at the University of Cambridge, UK, explain what lies behind the phrase “my stomach turns” when something disgusting is seen. According to the study, changes in the rhythm of our stomach lead us to look away from disgusting images.

Disgust is a natural response to unpleasant sights like rotten food, bodily waste, and weirdos, and it has evolved to help us survive, encouraging us to avoid things that could spread disease. But for some people, disgust can turn pathological and affect their mental health and quality of life.

In a study published Tuesday in the journal Current Biology, researchers from the Cognition and Brain Sciences Unit is a branch of the UK Medical Research Council show that domperidone, a commonly prescribed anti-nausea drug, can help to significantly reduce the number of volunteers looking at unpleasant images.

The domperidone acts to stabilize the rate of the electrical signals in the muscles of the stomach. Normally, these signals help the stomach expand and contract, helping to move food through the digestive tract. These rhythms become abnormal when we are nauseous or when we are hungry or full, for example. When they are strongly interrupted, for example, when we feel a strong repulsion towards something, they can cause us to vomit the contents of our stomach.

In the study, 25 volunteers between the ages of 18 and 35 were randomly assigned to one of two groups: one group to receive domperidone, the second a placebo.

Before taking their pills, the volunteers were shown a series of unpleasant images alongside neutral images, such as a scarf or buttons, while the researchers followed their eye movements. Thirty minutes after taking their tablets, the volunteers were shown the images again while their eye movements were tracked.

The researchers then offered an incentive to the volunteers: For every four to eight seconds they could look at an unpleasant image, they would receive 25 pence and hear a sound. The volunteers saw the images again for a final round, but this time without any incentive.
The volunteers were also asked to rate how disgusting they found the images at the beginning and end of the test.

Domperidone intake
The researchers found that initially, taking domperidone made little difference in the time volunteers spent looking at a particular image. As was to be expected between both groups, the dwell time increased dramatically when they were paid to look at the images.

In the final condition, when the volunteers were no longer incentivized, the team found that the volunteers who had received domperidone spent much more time than the placebo group looking at the disgusting images. In the end, people looked at the neutral image about 5.5 seconds longer than the disgusting image, but under the influence of domperidone, the difference was only 2.5 seconds. Domperidone did not influence how unpleasant the images were rated by the volunteers.

“We’ve known for some time that when you see something unpleasant, the electrical signals from the stomach muscles go out of regulation, which in some cases makes people feel sick or the stomach churns. So you’re likely to avoid that thing,” says Dr. Camilla Nord, from the MRC Brain Sciences and Cognition Unit at the University of Cambridge.

“What we have shown here is that when we stabilize the electrical signals of the stomach, people avoid an unpleasant image less after interacting with it,” he continues. “Changes in the rhythm of the stomach led to a reduction in the avoidance of displeasure in our study, so the rhythm of the stomach must be one of the causes of the avoidance of disgust in general. “

“In another recent study, we showed that we do not become immune to looking at disgusting images, a fact supported by the placebo status in this new study,” adds Dr. Edwin Dalmaijer, also from the MRC Unit. This is one of the reasons why those where the treatment of pathological disgust through exposure is often unsuccessful. Our research suggests that domperidone may help. “

“We have shown that by calming the rhythm of the stomach muscles with anti-nausea medications, we can help reduce our instinct to look away from a disgusting image,” explains Professor Tim Dalgleish, also from the MRC Unit, “but simply Using the drug itself is not enough: overcoming disgust avoidance requires that we be motivated or incentivized. This could provide us with clues as to how we can help people clinically overcome pathological disgust, which occurs in a number of mental health conditions and it can be disabling. “